Tetraben 12.5mg Tablet | 20pcs Box Price | Home delivery
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Tetraben 12.5mg Tablet 10pcs

Generic: Tetrabenazine

Type: Tablet

Pack Size: 10 Pcs

Tetraben 12.5mg Tablet is used to treat Huntington's disease and relieve uncontrollable and jerky movements of the body. 


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Discount Price: ৳ 190
MRP: ৳ 200 5% Off

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✅ Description:

  • Tetrabenazine belongs to a class of medicines called monoamine depletors.
  • It is used for treating involuntary movements (chorea) caused by Huntington's disease.
  • It works by reducing the amount of certain chemicals in the brain, such as norepinephrine, dopamine, and serotonin.
  • Tetrabenazine may cause several side effects, including feeling depressed, drowsiness, unusual muscle movements, dizziness, low blood pressure, nausea, upset stomach, difficulty sleeping, anxiety, confusion, difficulty swallowing, muscle stiffness, fever, sweating, and looking pale.
  • Before starting Tetrabenazine, your doctor needs to know if you are pregnant or breastfeeding, have liver, kidney, or heart problems, depression, Parkinson-like symptoms, a tumor on your adrenal gland, or are using any other medicines.
  • Do not take this medicine if you have ever had an allergic reaction to Tetrabenazine.

The information provided here is based on the salt content of the medicine. Uses and effects may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

Safety Advices


Alcohol
UNSAFE

It is unsafe to consume alcohol while taking Tetraben 12.5mg Tablet, as it may lead to excessive drowsiness.


Pregnancy
UNSAFE

Tetraben 12.5mg Tablet may be unsafe to use during pregnancy, as animal studies have shown harmful effects on the developing baby. Consult your doctor before using this medication if you are pregnant.


Breastfeeding
UNSAFE

Tetraben 12.5mg Tablet is probably unsafe to use during breastfeeding, as it may pass into breast milk and harm the baby. Consult your doctor before using this medication if you are breastfeeding.


Driving
CAUTION

Tetraben 12.5mg Tablet may decrease alertness, affect vision, or cause drowsiness and dizziness. It is unsafe to drive if you experience these symptoms.


Kidney
CONSULT YOUR DOCTOR

Limited information is available regarding the use of Tetraben 12.5mg Tablet in patients with kidney disease. Consult your doctor before using this medication if you have kidney problems.


Liver
CONSULT YOUR DOCTOR

Tetraben 12.5mg Tablet is probably unsafe to use in patients with liver disease, and it should be avoided. Consult your doctor for appropriate alternatives.

Similar Products

✔️ Uses of Tetraben 12.5mg Tablet
  • Huntington's Disease
✔️ How does Tetraben 12.5mg Tablet work?

It works by depleting the stores of certain chemical messengers in the brain that help control body movements.

✔️ Side Effects of Tetraben 12.5mg Tablet
  • Shortness of breath
  • Anxiety
  • Nausea and vomiting
  • Body pain
  • Chills and fever
  • Cough
  • Loss of balance control
  • Nasal congestion
  • Slurred speech
  • Sneezing
  • Sore throat
  • Loss of appetite
  • Restlessness
  • Difficult or painful urination
  • Trouble in speaking
  • Dizziness
✔️ Quick Suggestions:
  • You have been prescribed Tetraben 12.5 to help control movement disorders such as in Huntington’s disease.
  • Be cautious while driving or doing anything that requires concentration as Tetraben 12.5 can cause dizziness and sleepiness.
  • Inform your doctor if you experience symptoms such as high fever, sweating, muscle stiffness, and faster breathing. These may be due to a rare side effect known as the neuroleptic malignant syndrome.
  • Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
  • Do not stop taking Tetraben 12.5 without talking to your doctor first as it may cause worsening of symptoms.
✔️ Indications:

Treats diseases that cause hyperkinetic motor disorders (such as jerky, irregular, uncontrollable movements) associated with Huntington's chorea (an inherited neurodegenerative disease) in affected individuals

✔️ Pharmacology
  • Tetrabenazine reversibly inhibits human vesicular monoamine transporter type 2 (VMAT2), which leads to decreased uptake of monoamines (such as dopamine, serotonin, norepinephrine, and histamine) into synaptic vesicles.
  • This inhibition results in the depletion of monoamine stores from nerve terminals.
  • The mechanism is similar to reserpine but with less peripheral activity and is shorter-acting.
✔️ Dosage & Administration of Tetraben 12.5mg Tablet

Adult Dose:

For Huntington's Disease (chorea associated):

  • Start with 12.5 mg orally once daily.
  • After one week, increase to 12.5 mg every 12 hours.
  • Slowly titrate by weekly intervals of 12.5 mg/day to find a dose that reduces chorea and is well tolerated.
  • If the daily dose is between 37.5 to 50 mg, administer in divided doses every 8 hours.
  • For elderly patients, start with 12.5 mg daily and increase gradually.
  • If a dose higher than 50 mg/day is needed, test and genotype to determine metabolizer status. The maximum recommended daily dose is 100 mg/day or 37.5 mg per dose.

For moderate to severe tardive dyskinesia:

  • Start with 12.5 mg daily and increase gradually based on response.

Child Dose:

  • Safety and efficacy have not been established in children, so no specific dosing guidelines are available.

Special Populations:

  • Tetrabenazine is contraindicated in patients with hepatic impairment, as dose adjustment cannot ensure safe use.
✔️ Interaction

Tetraben 12.5mg Tablet not be given with or within 14 days of discontinuation of MAOI therapy. It may block the action of reserpine and decrease the effects of levodopa. There is an increased risk of extrapyramidal side effects when given certain medications like amantadine, metoclopramide, and antipsychotics.

✔️ Contraindications

Hypersensitivity. Lactation. Hepatic impairment. Patients who are actively suicidal, or who have untreated or inadequately treated depression.

✔️ Pregnancy & Lactation

Pregnancy:

  • There is limited data on the developmental risk associated with Tetrabenazine use in pregnant women.
  • Administration of Tetrabenazine to rats throughout pregnancy and lactation increased stillbirths and postnatal offspring mortality.
  • The potential risks and benefits of Tetrabenazine use during pregnancy should be carefully considered, and treatment should only be initiated if necessary.

Lactation:

  • There is no data on the presence of Tetrabenazine or its metabolites in human milk, its effects on breastfed infants, or milk production.
  • The developmental and health benefits of breastfeeding should be weighed against the potential adverse effects on the breastfed infant or underlying maternal condition.
✔️ Precautions & Warnings:
  • Tetrabenazine may exacerbate symptoms of parkinsonism, so caution should be exercised, especially when engaging in activities that require mental alertness, such as driving or operating machinery.
  • Pregnant patients should use Tetrabenazine with caution, and the potential risks and benefits should be discussed with a healthcare provider.
  • Patients with Huntington's disease may have an increased risk of depression and suicidal thoughts or behavior (suicidality) while taking Tetrabenazine.
  • It's essential to monitor for the emergence or worsening of depression, suicidality, or unusual changes in behavior, especially in patients with a history of depression or prior suicide attempts or ideation.
✔️ Storage Conditions

Keep Tetraben 12.5mg Tablet out of reach of children. Store Tetraben 12.5mg Tablet at room temperature

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